Immune Effector Cell-Associated Encephalopathy score not able to be calculated retrospectively. Time to relapse after first salvage with HD-MTX was similar to the time to relapse after initial treatment (25.8 months versus 24.4 months, respectively; Fig. Cox proportional-hazards models were fitted to estimate hazard ratios and to perform regression analysis. At time of infusion, 3 patients had parenchymal involvement, 3 had leptomeningeal involvement, and 2 had parenchymal and leptomeningeal involvement. Number of cycles of chemotherapy until initial response, time to initial response, and time to first relapse were used as predictors of second response, time to second relapse, and time to death from initial response. Not evaluable because of disease progression. doi: https://doi.org/10.1182/asheducation-2017.1.578. Matthew J. Frigault, Jorg Dietrich, Maria Martinez-Lage, Mark Leick, Bryan D. Choi, Zachariah DeFilipp, Yi-Bin Chen, Jeremy Abramson, Jennifer Crombie, Philippe Armand, Lakshmi Nayak, Chris Panzini, Lauren S. Riley, Kathleen Gallagher, Marcela V. Maus; Tisagenlecleucel CAR T-cell therapy in secondary CNS lymphoma. The records of patients with relapsed CNS lymphoma at the four participating institutions were reviewed. Regardless, the overall consequence of CNS relapse is often devastating, and for most patients, the median overall survival is typically only a few months, highlighting the need to accurately identify at-risk patients, screen for CNS disease, and develop safe and effective treatment/prophylaxis strategies. All of the patients received HD-MTX. D+28 response assessments also suggest that the kinetics of CAR T-cell efficacy within the CNS may be similar to systemic disease, because treatment responses were seen as early as 3 to 4 weeks after infusion. This information can guide both CNS staging investigations and prophylaxis strategies (see below). Search for other works by this author on: MYC-associated and double-hit lymphomas: a review of pathobiology, prognosis, and therapeutic approaches, An international evaluation of CODOX-M and CODOX-M alternating with IVAC in adult Burkitt’s lymphoma: results of United Kingdom Lymphoma Group LY06 study, Influence of rituximab on central nervous system relapse in diffuse large B-cell lymphoma and role of prophylaxis: a systematic review of prospective studies, Diffuse large B-cell lymphoma with involvement of the kidney: outcome and risk of central nervous system relapse, CNS events in elderly patients with aggressive lymphoma treated with modern chemotherapy (CHOP-14) with or without rituximab: an analysis of patients treated in the RICOVER-60 trial of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL), Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment, CNS international prognostic index: a risk model for CNS relapse in patients with diffuse large B-cell lymphoma treated with R-CHOP, Incidence and risk factors for central nervous system relapse in patients with diffuse large B-cell lymphoma: the impact of the addition of rituximab to CHOP chemotherapy, The number of extranodal sites assessed by PET/CT scan is a powerful predictor of CNS relapse for patients with diffuse large B-cell lymphoma: an international multicenter study of 1532 patients treated with chemoimmunotherapy, German High-Grade Non-Hodgkin’s Lymphoma Study Group (DSHNHL), Incidence and risk factors of central nervous system recurrence in aggressive lymphoma: a survey of 1693 patients treated in protocols of the German High-Grade Non-Hodgkin’s Lymphoma Study Group (DSHNHL), Highly elevated serum lactate dehydrogenase is associated with central nervous system relapse in patients with diffuse large B-cell lymphoma: Results of a multicenter prospective cohort study, Risk of CNS dissemination in extranodal lymphomas, Central nervous system event in patients with diffuse large B-cell lymphoma in the rituximab era, International Extranodal Lymphoma Study Group, Patterns of outcome and prognostic factors in primary large-cell lymphoma of the testis in a survey by the International Extranodal Lymphoma Study Group, Diffuse large B-cell lymphoma with testicular involvement: outcome and risk of CNS relapse in the rituximab era, First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial, Impact of rituximab on incidence of and risk factors for central nervous system relapse in patients with diffuse large B-cell lymphoma: a systematic review and meta-analysis, Uterine, but not ovarian, female reproductive organ involvement at presentation by diffuse large B-cell lymphoma is associated with poor outcomes and a high frequency of secondary CNS involvement, Primary paranasal sinus lymphoma: natural history and improved outcome with central nervous system chemoprophylaxis, The role of radiotherapy and intrathecal CNS prophylaxis in extralymphatic craniofacial aggressive B-cell lymphomas, Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone, Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone, A clinician’s guide to double hit lymphomas, Double hit lymphoma: the MD Anderson Cancer Center clinical experience, Impact of dual expression of MYC and BCL2 by immunohistochemistry on the risk of CNS relapse in DLBCL, German High-Grade Non-Hodgkin Lymphoma Study Group, MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma, MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell 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rituximab era: findings from a large national database, Flow cytometric characterization of cerebrospinal fluid cells, Detection and outcome of occult leptomeningeal disease in diffuse large B-cell lymphoma and Burkitt lymphoma, Evaluating cancer of the central nervous system through next-generation sequencing of cerebrospinal fluid, High doses of antimetabolites followed by high-dose sequential chemoimmunotherapy and autologous stem-cell transplantation in patients with systemic B-cell lymphoma and secondary CNS involvement: final results of a multicenter phase II trial, Intensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma, Dose-densified chemoimmunotherapy followed by systemic central nervous system prophylaxis for younger high-risk diffuse large B-cell/follicular grade 3 lymphoma patients: results of a phase II Nordic Lymphoma Group study, Low rates of CNS relapse in high risk DLBCL patients treated with R-CODOX-M and R-IVAC: results from a phase 2 UK NCRI/Bloodwise trial, Intravenous methotrexate as central nervous system (CNS) prophylaxis is associated with a low risk of CNS recurrence in high-risk patients with diffuse large B-cell lymphoma, A multicentre retrospective comparison of central nervous system prophylaxis strategies among patients with high-risk diffuse large B-cell lymphoma, Risk-tailored CNS prophylaxis in a mono-institutional series of 200 patients with diffuse large B-cell lymphoma treated in the rituximab era, Phase I study of dose-adjusted-Teddi-R with ibrutinib in untreated and relapsed/refractory primary CNS lymphoma, Lenalidomide plus R-CHOP (R2CHOP) in patients with DLBCL is associated with a lower risk of CNS relapse: combined analysis from two phase 2 studies, Recurrent genomic rearrangements in primary testicular lymphoma, Targetable genetic features of primary testicular and primary central nervous system lymphomas.

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