Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) are diseases of the elderly, with median age at diagnosis into the seventh decade of life [1,2]. After GVHD was controlled, MRD testing was repeated, and those patients that remained MRD+ received modified DLI. Conflicting impact of alloreactive NK cells on transplantation outcomes after haploidentical transplantation: do the reconstitution kinetics of natural killer cells create these differences? Allogeneic stem cell transplantation with HLA-matched donors is increasingly used for older patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Such transplantation was demonstrated to be a valid alternative as postremission treatment of intermediate- or high-risk AML patients in CR1 lacking an identical donor. Anderson Cancer Center, Houston, Texas. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Among the 8 patients who received chemotherapy alone, 2 patients achieved CR2 and are still alive (94 and 194 days after relapse) and 6 died at a median of 36 days after relapse. If you do not receive an email within 10 minutes, your email address may not be registered, There have been conflicting results regarding the impact of minimal/measurable disease at transplant on acute myeloid leukemia (AML) outcomes after haploidentical transplantation (haplo‐SCT). Higher rates of relapse in maternal recipients of haploidentical hematopoietic stem cell transplantation from adult offspring donors for AML and myelodysplastic syndrome. Bone Marrow Transplantation Department of Medical Oncology, Kimmel Cancer Center, Philadelphia, PA, USA, P R Geethakumari, S O Alpdogan, M Carabasi, J Filicko-O’Hara, S Gaballa, M Kasner, T Klumpp, U Martinez-Outschoorn, N Palmisiano, J L Wagner, P Porcu, N Flomenberg & D Grosso, Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA, Department of Epidemiology and Biostatistics, Temple University, Philadelphia, PA, USA, You can also search for this author in After a median follow-up of 19 months (range, 6 to 49), 20 of 43 patients were alive and in remission. The effect of tolerance to noninherited maternal HLA antigens on the survival of renal transplants from sibling donors. Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide. Haploidentical- versus identical-sibling transplant for high-risk pediatric AML: A multi-center study. Impact of donor age and kinship on clinical outcomes after T-cell-replete haploidentical transplantation with PT-Cy. wrote the manuscript; X.-J.H. Survival after T cell depleted haploidentical stem cell transplantation is improved using the mother as donor. Except for 1 patient who had early death, the remaining 42 patients (98%) engrafted donor cells. and Q.-F.L. Patients were divided into three groups based on their relationship to the donor: maternal, paternal and sibling recipients. Information on NPM1 was available in 222 patients (normal karyotype with NPM1 mutation and FLT3-ITD in 11 patients, abnormal karyotype with NPM1 mutation in 11 patients, normal karyotype with NPM1 wild type in 110 patients, and abnormal karyotype with NPM1 wild type in 90 patients). Article  Haploidentical transplants for patients with relapse after the first allograft. Wilms’ tumor gene 1 expression: an independent acute leukemia prognostic indicator following allogeneic hematopoietic SCT. Taken together, we hypothesized that haploidentical HSCT is a valid option as a postremission treatment of AML in CR1. They had hazard ratios (HR) of 3.5 (95% CI: 2.05‐6.1; P < .001) and 2.3 (95% CI: 1.3‐3.9; P = .002), respectively. A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: a risk factor analysis of outcomes for patients in remission at transplantation. The analysis includes data collected as of November 30, 2014. Epub 2019 May 18. Although OS is similar, a matched sibling transplant should still be considered the standard of care, compared with haploidentical transplants since it has lower morbidity (GVHD) and NRM. Biol Blood Marrow Transplant 2016; 22: 23–26. Haploidentical transplant achieves outcomes similar to those of identical-sibling transplant for AML patients in first remission. and JavaScript. Recent Advances in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia. and Q.-F.L. Consecutive patients receiving HID (n = 231) or ISD (n = 219) HSCT during the study period were enrolled. All the more, although the effects of HLA-matched allo-HSCT on patients with AML in CR1 are well established,1-5  the application of haploidentical HSCT in AML needs to be broadened.29,30  Our observations support the rationale for considering haploidentical HSCT as a front-line postremission treatment option for adults with AML without favorable cytogenetics who lack a matched donor. Wang Y, Chang Y, Xu L, Liu KY, Liu DH, Zhang XH et al. Relapse, nonrelapse mortality (NRM), engraftment, and GVHD were estimated as cumulative incidences, taking into account competing risks. Among the 23 patients (13 HID, 10 ISD) receiving modified DLI as intervention for positive MRD, 7 (4 of 13 HID and 3 of 10 ISD) eventually relapsed at a median of 194 days (range, 85-780 days) after DLI, and 15 patients were alive without relapse with a median of 940 days (range, 214-1349 days) after DLI; the remaining 1 patient died of infection. The effects of HLA-identical sibling donor (ISD) hematopoietic stem cell transplantation (HSCT) on adults with intermediate- or high-risk acute myeloid leukemia (AML) in the first complete remission (CR1) are well established. Acute Leukemia Working Party (ALWP) of European Blood and Marrow Transplant (EBMT) Group. Blood Adv. The detailed criteria for preemptive DLI administration included the following: (1) patients scored as MRD+ if they had 2 consecutive positive results using flow cytometry or Wilms’ tumor gene 1 or were both flow cytometry–positive and Wilms’ tumor gene 1– positive in a single sample within 1 year after transplantation; (2) no uncontrolled GVHD or life-threatening infection; and (3) with donor availability and willingness. Granulocyte colony-stimulating factor (G-CSF; 5 µg/kg of body weight per day for 5 days) was used to mobilize the BM and PB.

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