Classic Hodgkin lymphoma (CHL) is a monoclonal lymphoid neoplasm (in most instances derived from B cells) composed of mononuclear Hodgkin and multinucleated Hodgkin Reed-Sternberg (HRS) cells residing in an infiltrate containing a variable mixture of nonneoplastic small lymphocytes, eosinophils, neutrophils, histiocytes, plasma cells, fibroblasts and collagen fibers (WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues… The prognosis for myeloma in older individuals is poor although new agents that inhibit the proteosome (inducing apoptosis by causing degradation of NFκB in neoplastic plasma cells) have shown some promise in myeloma that is refractory to other forms of chemotherapy. Please note that these links will take you to other sections on Cancer.Net: Cancer.Net En Español: Read about Hodgkin lymphoma in Spanish. 5.8).4 Conversely, H/RSCs in CHL are heterogeneous with respect to expression of BCL-6 and CD138, reflecting their mixed germinal center or post–germinal center origin. The prognosis for myeloma in older individuals is poor although new agents that inhibit the proteosome (inducing apoptosis by causing degradation of NFκB in neoplastic plasma cells) have shown some promise in myeloma that is refractory to other forms of chemotherapy. In addition, IL-13 is produced by many RS cells and can bind to IL-13 receptor on their surface, resulting in an autocrine loop that promotes cell proliferation. Parul Bhargava, Marshall E. Kadin, in Diagnostic Immunohistochemistry (Third Edition), 2011. Nine primary cases of cHL and four cell lines were assessed for RNA expression, expressed mutations, cell type of origin, signaling pathways, gene fusions and pathogen identification. Debra L. Friedman, in Lanzkowsky's Manual of Pediatric Hematology and Oncology (Sixth Edition), 2016. Consistent with plasma cell differentiation, we uncovered an unfolded protein response UPR) signature, shared with plasma cell neoplasms and, to a lesser extent, activated B cell (ABC) diffuse large B cell lymphoma, but not other B cell lymphoma types, including primary mediastinal B cell lymphoma (PMBCL). Thank you. If you would like more of an introduction, explore this related item. Details : Home | Authors | Contact | Terms of use | Privacy Policy | References, Copyright © 2004 - 2016 Atlas of Pathology. In addition to Reed-Sternberg cells, there are bands of connective tissue (called fibrosis) found in the lymph node. Some cases of myeloma are poorly differentiated, making them difficult to recognize as plasma cell tumors. The diagnosis criteria are : tumor component Neutrophils and eosinophils have been reported in lesions from all these conditions and are not a discriminating feature. Unfortunately, however, the paucity of these cells in organs involved by HD has made it impossible to achieve definite results. Although the HRS cells of cHL and NLPHL share certain mechanisms of tumorigenesis (eg, activation of the NF-kB pathway), they also differ with regard to immunophenotype, specific genetic abnormalities, and the role of immune evasion in tumor growth and survival. A common variety of these cells has at least two nuclei, giving them the appearance of owls' eyes. Most patients with MUGUS do not develop signs and symptoms of myeloma in their lifetime. Variants of Reed-Sternberg cell (H&E, ob.x20) : The recently launched journal Archive of Clinical Cases welcomes submission for publication of original papers - clinical cases covering all fields of Medicine. eosinophils, plasma cells, neutrophils, fibrosis and capillaries). CD30 (a marker of activated lymphocytes) (Stein et al., 1982, 1985) is consistently present on the RS cell surface and its expression is accompanied by other lymphocyte activation markers, such as the MHC class II antigens, CD45, and CD25 (Casey et al., 1989; Schwab et al., 1982; Stein et al., 1985). The largest groups of lymph nodes are found in the chest, abdomen, groin, pelvis, underarms, and neck. Second, RS cells often associate in involved lymph nodes with T lymphocytes showing the CD4 (helper/inducer) phenotype, as interdigitating antigen-presenting reticulum cells in the thymus-dependent areas of lymphoid tissues usually do.

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